Netherhall House is a corporate undertaking of Opus Dei, a personal Prelature of the Catholic Church. Daily Mass is celebrated for those who wish to attend.

Other spiritual activities are organised such as seminars on Christian faith, retreats, and praying of the Rosary. All students are welcome to participate in these activities, whatever their creed, but are also totally free not to.

The hall has a resident chaplain, at present Fr Joseph Evans. Fr Joseph is also Roman Catholic chaplain to SOAS, Birkbeck College, and the Institute for the Study of the Americas, as part of the University of London chaplaincy team.